pI: 8.0739 |
Length (AA): 469 |
MW (Da): 52729 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 469 | 4r7p (A) | 55 | 508 | 65.00 | 0 | 1 | 1.7836 | -0.8 |
1 | 469 | 2i5k (A) | 52 | 499 | 53.00 | 0 | 1 | 1.6046 | -0.56 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128034)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G17310 | UTP--glucose-1-phosphate uridylyltransferase 1 |
Arabidopsis thaliana | AT3G03250 | UDP-GLUCOSE PYROPHOSPHORYLASE 1 |
Brugia malayi | Bm1_41320 | UDP-glucose pyrophosphorylase |
Candida albicans | CaO19.9305 | similar to S. cerevisiae UGP1 (YKL035W) uridinephosphoglucose pyrophosphorylase involved in protein amino acid glycosylation |
Candida albicans | CaO19.1738 | similar to S. cerevisiae UGP1 (YKL035W) uridinephosphoglucose pyrophosphorylase involved in protein amino acid glycosylation |
Caenorhabditis elegans | CELE_K08E3.5 | Protein K08E3.5, isoform A |
Dictyostelium discoideum | DDB_G0277879 | UDP-glucose pyrophosphorylase 2 |
Drosophila melanogaster | Dmel_CG4347 | CG4347 gene product from transcript CG4347-RE |
Echinococcus granulosus | EgrG_000193500 | UTP glucose 1 phosphate uridylyltransferase |
Echinococcus granulosus | EgrG_000843500 | UTP glucose 1 phosphate uridylyltransferase |
Entamoeba histolytica | EHI_000440 | UDP-glucose pyrophosphorylase, putative |
Echinococcus multilocularis | EmuJ_000843500 | UTP glucose 1 phosphate uridylyltransferase |
Echinococcus multilocularis | EmuJ_000193500 | UTP glucose 1 phosphate uridylyltransferase |
Giardia lamblia | GL50803_29307 | UTP-glucose-1-phosphate uridylyltransferase |
Homo sapiens | ENSG00000169764 | UDP-glucose pyrophosphorylase 2 |
Leishmania braziliensis | LbrM.18.1050 | UDP-glucose pyrophosphorylase |
Leishmania donovani | LdBPK_180990.1 | UDP-glucose pyrophosphorylase |
Leishmania infantum | LinJ.18.0990 | UDP-glucose pyrophosphorylase |
Leishmania major | LmjF.18.0990 | UDP-glucose pyrophosphorylase |
Leishmania mexicana | LmxM.18.0990 | UTP-glucose-1-phosphate uridylyltransferase 2, putative |
Loa Loa (eye worm) | LOAG_16072 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06817 | UDP-glucose pyrophosphorylase |
Loa Loa (eye worm) | LOAG_09471 | hypothetical protein |
Mus musculus | ENSMUSG00000001891 | UDP-glucose pyrophosphorylase 2 |
Oryza sativa | 4328091 | Os02g0117700 |
Oryza sativa | 4347800 | Os09g0553200 |
Saccharomyces cerevisiae | YKL035W | UTP glucose-1-phosphate uridylyltransferase |
Schistosoma japonicum | Sjp_0043990 | ko:K00963 UTP--glucose-1-phosphate uridylyltransferase [EC2.7.7.9], putative |
Schistosoma mansoni | Smp_133600 | utp-glucose-1-phosphate uridylyltransferase 2 (udp-glucose pyrophosphorylase 2) |
Schmidtea mediterranea | mk4.001264.03 | |
Schmidtea mediterranea | mk4.000070.17 | UTPALQ-glucose-1-phosphate uridylyltransferase |
Schmidtea mediterranea | mk4.001264.04 | |
Schmidtea mediterranea | mk4.000070.15 | |
Schmidtea mediterranea | mk4.000070.19 | UTPALQ-glucose-1-phosphate uridylyltransferase |
Schmidtea mediterranea | mk4.000090.06 | UTPALQ-glucose-1-phosphate uridylyltransferase |
Trypanosoma brucei gambiense | Tbg972.10.15880 | UTP-glucose-1-phosphate uridylyltransferase 2, putative |
Trypanosoma brucei | Tb927.10.13130 | UTP-glucose-1-phosphate uridylyltransferase |
Trypanosoma congolense | TcIL3000_10_11210 | UTP-glucose-1-phosphate uridylyltransferase 2, putative |
Trypanosoma cruzi | TcCLB.503521.50 | UTP-glucose-1-phosphate uridylyltransferase 2, putative |
Trypanosoma cruzi | TcCLB.506359.60 | UTP-glucose-1-phosphate uridylyltransferase 2, putative |
Trichomonas vaginalis | TVAG_518540 | UDP- glucose pyrophosphorylase, putative |
Trichomonas vaginalis | TVAG_388260 | utp-glucose-1-phosphate uridylyltransferase, putative |
Trichomonas vaginalis | TVAG_102390 | utp-glucose-1-phosphate uridylyltransferase, putative |
Trichomonas vaginalis | TVAG_247480 | UDP- glucose pyrophosphorylase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_K08E3.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K08E3.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K08E3.5 | Caenorhabditis elegans | slow growth | wormbase |
YKL035W | Saccharomyces cerevisiae | inviable | yeastgenome |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.